A rare case of intracranial Castleman disease

Introduction . Castleman disease (CD) is a rare lymphoproliferative disorder also known as angiofollicular lymph node hyperplasia or giant lymphoid hyperplasia. CD considered unicentric in the presence of single focus and if clinical picture represented by multiple lymphadenopathy systemic manifestations, it multicentric. Manifestation occurrence that mimics tumor meninges brain extremely rare, only 20 cases are including one presented our article. The main treatment for localized forms surgical resection. Our observation devoted to variant intracranial CD. Description case Woman, 35 years old, was admitted clinic with complaints recurrent headache moderate intensity diffuse nature difficulty counting writing. A month before hospitalization generalized epileptic seizure occurred. In at time admission, Gerstmann-Schilder syndrome noted which topically corresponded lesion right parietal lobe. MRI contrast enhancement showed pathological infiltration structure bone, massive paraosseous component spread intracranially compression lobe, moderately pronounced perifocal edema. neoplasm removed totally fragment dura mater (DM). plastic DM performed vascularized periosteal flap one-stage skull defect titanium implant. According histological immunochemical studies, well additional examinations, diagnosis established. results control after 3, 6 12 months, data relapse were not revealed. patient currently does report any symptoms disease. Conclusion Intracranial benign amenable radical require further adjuvant therapy. Despite complexity differential between meningiomas, primary strategy remains same all cases: total removal.